Bone loss does not begin with a DEXA scan.
It begins quietly at the cellular level through inflammation you cannot feel, micro-fractures you never knew were there, and age-related changes that slowly shift your bones toward breakdown instead of rebuilding.
By the time osteopenia or osteoporosis shows up on a report, the real question becomes: Why is this happening, and can your bones recover?
That is exactly what we cover in this episode.
I invited Kiran Krishnan back for a second conversation to break down what truly drives bone loss, fracture healing, and long-term bone strength. We explore how aging, inflammation, circulation, and targeted nutrients influence
bone remodeling and bone quality.
Episode Details
Episode Timeline
0:00 - Episode start
3:11 - Introducing today’s guest, Kiran Krishnan
7:11 - Understanding the anabolic vs catabolic balance and early bone degeneration
9:58 - Why bone resorption overtakes bone formation and weakens bone repair
13:02 - Understanding bone density vs. bone quality and how they create true bone strength
13:35 - Dalbergia sissoo’s dual action: increasing osteoblasts and reducing osteoclasts for stronger bones
19:57 - Why DEXA scans only show bone density and miss important bone quality changes
21:16 - Why athletes and younger adults also need bone matrix support to prevent micro-fractures
26:58 - How vitamin D3 and vitamin K2 MK-7 work together to direct calcium into bones
27:49 - The calcium paradox: why calcium without K2 increases cardiovascular risk and doesn’t fix osteoporosis
33:14 - Safe and effective dosing for Dalbergia sissoo for bone regeneration
36:06 - How improving trabecular bone reduces bone pain, stiffness, and fatigue in early osteopenia
41:10 - Combining Dalbergia sissoo, vitamin D3 and vitamin K2 for a comprehensive stronger bones strategy
42:51 - Why bone health should start decades before your first DEXA scan
45:33 - Where listeners can connect with Kiran Krishnan
Resources mentioned
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About the guest
Kiran Krishnan is a research microbiologist and health expert known for making complex science easy to understand.
Over the past 20 years, Kiran has founded and led multiple health and supplement companies, including co-founding Microbiome Labs, now one of the most trusted microbiome-focused brands among healthcare practitioners. He has published scientific research, holds global patents, and is a sought-after speaker on human health and the microbiome. Kiran blends scientific rigor with real-world clarity, helping people understand the mechanisms that drive better health from the inside out.
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