Nitric oxide has a quiet yet important role in your overall resilience: from circulation, cognitive clarity, including your bone strength as you age.
While many associate nitric oxide with workout performance or sexual health, its role in bone remodeling, cardiovascular function, and cellular signaling often goes overlooked. That’s why revisiting this conversation is so important.
In this episode, I speak with Brendan Vermeire, a functional medicine practitioner and nitric oxide researcher, about how this foundational signaling molecule influences blood vessel health, bone formation, metabolic function, and postmenopausal physiology. We also explore practical strategies to support nitric oxide production naturally, including movement, sunlight exposure, nasal breathing, and dietary nitrates from leafy greens, along with how measuring salivary nitrite can provide real-time insight into your levels.
If you’re committed to protecting your bones, improving circulation, and supporting whole-body health as you age, this episode offers a deeper understanding of how nitric oxide fits into the bigger picture.
Episode Details
Episode Timeline
00:00 – Episode Start
04:38 – Brendan’s Journey into Health & Functional Medicine
08:27 – What Is Nitric Oxide and Why It Matters
10:07 – Nitric Oxide Beyond Performance and Sexual Health
11:38 – How Nitric Oxide Is Produced in the Body
11:43 – The Nitrate Pathway vs. Arginine Pathway
14:07 – Aging, Inflammation, and Nitric Oxide Decline
18:24 – Nitric Oxide and Bone Health
19:39 – Lifestyle Ways to Naturally Boost Nitric Oxide
21:43 – Salivary Nitrite Testing and Measuring Levels
25:56 – Practical Application and Supplementation
29:09 – Chronic Disease, Cardiovascular Risk & Women’s Health
30:59 – Closing Thoughts on Smarter Healing
33:22 – Where to Find Bernard Vermiere
Resources mentioned
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About the guest
Joining us today to explore nitric oxide and its connection to bone health, cardiovascular function, and healthy aging is Brendan Vermeire.
Brendan Vermeire is a functional medicine practitioner, educator, and founder of Metabolic Solutions LLC. With a deep focus and research on nitric oxide physiology, cardiometabolic health, and chronic disease prevention, Brendan has dedicated his career to understanding how cellular signaling impacts energy, circulation, bone remodeling, and long-term resilience. Through clinical work and education, he helps bridge emerging research with practical application to support optimal health and aging.
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